Anti-ATL1 Antibody

Atlastin-1 (ATL1) is a dynamin-related GTPase that drives homotypic fusion of endoplasmic reticulum tubules, giving the ER its characteristic polygonal network. Loss-of-function mutations in ATL1 cause SPG3A, the most common autosomal dominant form of hereditary spastic paraplegia, making detection of this protein central to studies of ER membrane dynamics, axon maintenance, and motor neuron biology.

This unconjugated rabbit polyclonal antibody from Antibodies.com was raised against human ATL1 and is qualified for Western blot, immunohistochemistry, and immunofluorescence on human samples. Supplied as a 100 µL aliquot of polyclonal serum, the reagent binds atlastin-1 in both denatured and native contexts and is useful for probing patient fibroblasts carrying SPG3A alleles, iPSC-derived motor neurons, and tissue sections from the corticospinal tract.

Researchers investigating ER tubulation, GTPase mechanism, or HSP pathology can combine it with organelle markers such as calnexin or reticulon-4 to localize atlastin-1 at the subcellular level. Refrigerate on arrival and protect from repeated freeze-thaw cycles to preserve activity across multiple experiments.