Anti-ATF4 Antibody

Raised in rabbit against activating transcription factor 4, this unconjugated polyclonal antibody from Antibodies.com targets a key effector of the integrated stress response. ATF4 is a basic leucine zipper transcription factor that coordinates gene expression programs governing amino acid metabolism, redox homeostasis, and autophagy during endoplasmic reticulum stress.

Supplied in 100 µl, the reagent is validated for western blot and immunohistochemistry workflows and cross-reacts with human, mouse, and rat samples, supporting translational studies across in vitro cell culture models and tissue analysis. Researchers commonly probe ATF4 induction following thapsigargin or tunicamycin treatment, as well as amino acid starvation, to monitor PERK and GCN2 pathway activation in cancer biology, osteoblast differentiation, and metabolic disease research.

For best results, store aliquots frozen at -20 degrees C and limit freeze-thaw cycles to preserve antibody titer for reproducible band detection across experimental replicates.