Anti-ASS1 Antibody

Argininosuccinate Synthase 1 (ASS1) is a cytosolic enzyme that catalyzes the ATP-dependent formation of argininosuccinate from citrulline and aspartate, a key step in the urea cycle and de novo arginine biosynthesis. This rabbit polyclonal antibody from Antibodies.com is raised against human ASS1 and is validated for Western blot and immunohistochemistry workflows. The unconjugated reagent is supplied at 100 µl, supporting flexible dilution across blotting and section-staining protocols.

Downregulation of ASS1 is a documented metabolic feature of arginine-auxotrophic tumors, including hepatocellular carcinoma, melanoma, and subsets of breast and prostate cancers, where the protein has been studied as a biomarker for arginine deprivation therapies. The antibody is equally relevant to inherited metabolism research, since ASS1 deficiency causes citrullinemia type I, a urea cycle disorder in which hepatic and renal expression patterns are typically examined. As a polyclonal reagent raised in rabbit, the antibody recognizes multiple epitopes on ASS1, helping to deliver consistent signal across lysate-based and fixed-tissue applications.