Anti-ASNS Antibody

Asparagine synthetase (ASNS) catalyzes the ATP-dependent synthesis of asparagine from aspartate and glutamine, linking amino acid biosynthesis to the integrated stress response through GCN2, eIF2α phosphorylation, and ATF4 transcriptional control. This unconjugated rabbit polyclonal primary antibody, supplied by Antibodies.com as a 100 µl vial, was raised against ASNS and is validated for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat sample preparations. The reagent supports studies of cancer cell amino acid metabolism, asparagine auxotrophy, and the cellular response to nutrient deprivation or oncogenic stress, where altered ASNS expression marks both adaptive translational programs and resistance phenotypes relevant to L-asparaginase chemotherapy research. Investigators probing the unfolded protein response, ER stress signaling, and tumor microenvironment adaptations routinely monitor ATF4 target gene induction through ASNS detection in cell culture and tissue-based assays.