Anti-ASK1 (phospho-S83) Antibody

Antibodies.com provides this rabbit polyclonal antibody raised against ASK1 (Apoptosis Signal-regulating Kinase 1, also known as MAP3K5) when phosphorylated at serine 83. The phospho-S83 epitope marks a regulatory site on the kinase that governs its activation within stress-activated MAPK signaling cascades, including the JNK and p38 pathways that drive inflammatory and apoptotic responses. Investigators working on cellular stress, oxidative damage, cytokine signaling, or kinase regulation use phospho-specific reagents to distinguish the activated pool of ASK1 from total protein in fixed tissue sections.

Supplied as 100 µl of unconjugated antibody at 1 mg/ml in a single-use vial of phosphate buffered saline containing 0.05% sodium azide (approximately pH 7.2), the reagent is validated for immunohistochemistry on human samples and is intended for research use only. The polyclonal format broadens epitope coverage around the phospho-serine 83 residue, supporting detection across a range of fixation and antigen retrieval protocols commonly used in pathology workflows. The product is a Primary Antibodies reagent with reactivity to human ASK1 and is unconjugated, allowing flexible pairing with secondary detection systems of the researcher's choice.