Anti-ASK1 (Ab-83) Antibody

Raised in rabbit against the ASK1 kinase, this polyclonal reagent from Antibodies.com targets Apoptosis Signal-regulating Kinase 1 (MAP3K5), a stress-activated MAP kinase kinase kinase that propagates JNK and p38 signaling downstream of oxidative stress, TNF receptor activation, and endoplasmic reticulum challenge. The unconjugated IgG fraction is supplied as a 100 µl liquid aliquot and is validated for western blot detection of endogenous ASK1 levels in human cell lysates, as well as immunohistochemistry and immunofluorescence staining of fixed tissue sections. Because the immunogen corresponds to a defined residue on the ASK1 polypeptide, the antibody supports studies of kinase regulation, apoptosis pathway dissection, and crosstalk between stress-response cascades. Standard storage at -20 °C in single-use aliquots preserves activity across multiple freeze-thaw cycles, and the polyclonal format allows recognition of multiple epitopes for robust signal in denaturing and native sample preparations.