Anti-ARSB Antibody

Arylsulfatase B (ARSB) is a lysosomal sulfatase that hydrolyzes sulfate ester bonds on N-acetylgalactosamine-4-sulfate residues of chondroitin-4-sulfate and dermatan sulfate glycosaminoglycans. Loss-of-function mutations in ARSB cause mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy syndrome), a lysosomal storage disorder presenting with progressive skeletal dysplasia, corneal clouding, and cardiac involvement, making reliable protein-level detection of this enzyme important for both disease model characterization and the evaluation of enzyme replacement and gene therapy strategies.

This polyclonal reagent from Antibodies.com is raised in rabbit and is supplied as an unconjugated primary antibody validated for Western blot applications across human, mouse, and rat sample types. The immunoglobulin is formulated at 1 mg/ml in phosphate-buffered saline at approximately pH 7.9, with 0.05% sodium azide included as a preservative, and ships in a 100 µl volume that supports several blotting experiments depending on membrane size and probing conditions. Because the antibody is unconjugated, it can be paired with an HRP- or fluorophore-conjugated secondary antibody selected to match the detection chemistry of the Western blot workflow. The polyclonal nature of the reagent increases the likelihood of recognizing multiple epitopes on ARSB, which can be useful when probing samples where protein truncation or post-translational modification may otherwise compromise signal from a single epitope.