Anti-ARSA Antibody

ARSA (Arylsulfatase A) is a lysosomal hydrolase that catalyzes the desulfation of cerebroside sulfate and is most studied in the context of Metachromatic Leukodystrophy, a rare autosomal recessive disorder caused by loss-of-function mutations in the ARSA gene. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against ARSA and validated for Western blot and immunohistochemistry workflows, enabling detection of the endogenous protein in tissue sections and lysates prepared from human, mouse, and rat samples. Supplied as 100 µl of polyclonal antiserum, the antibody is suitable for probing expression patterns in neuronal and glial cell populations, as well as for characterization of patient-derived fibroblasts or animal models of sulfatide accumulation. Researchers commonly apply this reagent to investigate lysosomal biogenesis, microglial activation, and demyelination pathways relevant to neuroinflammatory and neurodegenerative disease studies, and it can be paired with secondary antibodies for chromogenic or fluorescent visualization depending on the detection platform in use.