Anti-Arrestin-β-1 Antibody

β-arrestin 1 (Arrestin-β-1) is a multifunctional scaffold protein best known for terminating G protein-coupled receptor (GPCR) signaling while simultaneously initiating β-arrestin-dependent cascades such as MAPK activation, PI3K/AKT, and non-canonical Wnt signaling. This unconjugated recombinant rabbit monoclonal antibody from Antibodies.com is raised against Arrestin-β-1 and supplied as 100 µl of antibody in a stabilising buffer of 1× TBS (pH 7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative.

Validated for Western blot (WB), immunocytochemistry and immunofluorescence (ICC/IF), and immunohistochemistry on flow-cytometry samples (IHCFC) in human, mouse, and rat specimens, the reagent supports cross-species comparative work ranging from neuroscience to cardiovascular and oncology research. Investigators use β-arrestin 1 antibodies to characterise receptor desensitisation, internalisation, and biased agonism at GPCRs, as well as arrestin-mediated signal cross-talk. For best results, store refrigerated, aliquot to limit freeze-thaw cycles, and protect from light to preserve antibody activity.