Anti-Arrestin-β-1 Antibody

Antibodies.com offers this unconjugated rabbit polyclonal antibody against Arrestin-β-1, a cytosolic scaffolding protein central to G-protein-coupled receptor (GPCR) desensitization and downstream β-catenin and MAPK signaling. Raised in rabbit and supplied at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, the reagent ships as a 100 µl vial suitable for extended bench use. Validation covers Western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples, making it useful for studying receptor internalization dynamics, desensitization kinetics, and arrestin-mediated signalosome assembly in cell biology and neuroscience research. Aliquoting on first use is recommended to limit freeze-thaw cycles of the glycerol stock, while the unconjugated format allows conjugation to a reporter of choice or direct use in chromogenic and fluorescence detection systems. The polyclonal nature provides recognition of multiple epitopes on the target, an advantage when probing denatured lysates or partially processed tissue sections.