Anti-ARRB1 Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets ARRB1 (β-arrestin 1), a multifunctional scaffolding protein that mediates desensitization of activated G protein-coupled receptors and modulates downstream MAPK, PI3K/AKT, and Wnt/β-catenin signaling cascades. Supplied as a 100 µl liquid aliquot in a single vial, the reagent is validated for Western blot, immunohistochemistry, and immunofluorescence workflows.

The antibody shows confirmed reactivity with human, mouse, and rat ARRB1, producing staining patterns consistent with the protein's known cytoplasmic and membranous distribution. It is frequently applied in studies of receptor internalization, β-arrestin-biased agonism, chemokine-driven cell migration, and aberrant signaling in cardiovascular and tumor models. This reagent is routinely used to map ARRB1 expression in primary cultures, organoid preparations, and archived tissue sections.

Store refrigerated between uses; brief centrifugation before opening collects the full volume from the cap and walls. Aliquoting after first thaw preserves activity and minimizes repeated freeze-thaw stress on the polyclonal pool. Intended for research use only.