Anti-ARPC2 Antibody

ARPC2 (Actin-Related Protein 2/3 Complex Subunit 2) is a ~34 kDa core component of the seven-subunit Arp2/3 complex that nucleates branched actin filament networks at the leading edge of motile cells. This unconjugated polyclonal reagent from Antibodies.com is supplied as 100 µl of liquid antiserum, raised in Rabbit host and validated for western blot and immunohistochemistry on human, mouse, and rat samples.

ARPC2 (also known as p34-Arc and ARC34) stabilizes the short-lived active conformation of the Arp2/3 complex and is required for lamellipodial actin assembly, cell migration, endocytosis, and phagocytosis. Loss or knockdown of ARPC2 in published studies abolishes Arp2/3-mediated actin branching and impairs invadopodia formation in metastatic cancer models, making this antibody relevant for cytoskeleton remodeling, chemotaxis, and tumor invasion research.

Recommended applications include western blot detection of the endogenous 34 kDa band in lysates from human cell lines, and immunohistochemistry on frozen or formalin-fixed paraffin-embedded tissue sections. The reagent is Rabbit host, Polyclonal clonality, with no fluorophore or enzyme tag, allowing flexible pairing with secondary reagents of the user's choice. Aliquot upon receipt and store refrigerated short term; freeze at -20 degrees C for long-term storage and limit freeze-thaw cycles to preserve activity.