Anti-ARPC2 Antibody

Antibodies.com offers a rabbit polyclonal reagent raised against Actin-Related Protein 2/3 Complex Subunit 2 (ARPC2, also referred to as p34-ARC/ARC34), a core component of the seven-subunit Arp2/3 complex that nucleates branched actin filament networks at the leading edge of migrating cells, at sites of clathrin-mediated endocytosis, and within immune synapses. The unconjugated antibody is supplied in a 100 µl volume and has been validated in western blot, immunohistochemistry, and immunofluorescence workflows, with demonstrated reactivity against human and mouse samples. The Arp2/3 complex has been linked to lamellipodial protrusion, invadopodium assembly in metastatic cells, and cortical actin remodeling during cytokinesis, making this reagent useful for cytoskeletal research, cell migration studies, and investigations of actin-dependent membrane trafficking. Polyclonal reactivity supports recognition of multiple epitopes on the ~34 kDa ARPC2 subunit, which can be helpful when probing samples where post-translational modification or partial proteolysis of binding partners is a concern.