Anti-ARHGEF18 Antibody

This rabbit polyclonal antibody targets ARHGEF18, a Rho-family guanine nucleotide exchange factor that activates RhoA signaling and plays a documented role in endothelial lumen formation, cytoskeletal dynamics, and cell migration. The unconjugated reagent is supplied by Antibodies.com in a 100 µl volume and is validated for Western blot and immunofluorescence applications on human samples.

ARHGEF18, also referred to in the literature as p114-RhoGEF or AARGEF18, has been investigated in studies of vascular biology, glioblastoma cell motility, and epithelial morphogenesis, making this reagent relevant for researchers examining Rho-GEF signaling, junctional integrity, and tumor cell invasion. The polyclonal format provides multi-epitope recognition of the target, which can be advantageous when probing endogenous protein expression across tissues or cell lines.

This antibody is specific to human ARHGEF18, supporting studies in human cell models and tissue specimens. Recommended handling includes aliquoting upon receipt to limit repeated freeze-thaw cycles and preserve reagent performance across multiple experiments. Researchers studying RhoA-mediated contractility, VE-cadherin–dependent adhesion, or angiogenic sprouting will find this antibody useful as a primary detection reagent for both immunoblotting and fluorescence-based imaging workflows.