Anti-ARHGAP44 Antibody

Antibodies.com offers a rabbit polyclonal antibody raised against ARHGAP44, supplied as an unconjugated primary antibody for research use. The reagent is intended for Western blotting (WB) and immunohistochemistry (IHC) and reacts with human samples.

The antibody is raised in rabbit, is polyclonal, and is supplied unconjugated. It is formulated at 1mg/ml in PBS with 0.1% Sodium Azide and 50% Glycerol. The immunogen was recombinant full length Human ARHGAP44, and the reagent detects endogenous levels of ARHGAP44 protein. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen, and the purity is greater than 95% as determined by SDS-PAGE. The target protein has a molecular weight of approximately 89kDa.

ARHGAP44 is a GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases, thereby controlling their cycling between active GTP-bound and inactive GDP-bound states. It may act as a GAP for CDC42 and RAC1. The protein also functions as an endosomal recycling factor that, in association with SHANK3, contributes to synaptic plasticity, promotes GRIA1 exocytosis from recycling endosomes, and supports spine morphological changes associated with long-term potentiation.