Anti-ARG1 Antibody

This unconjugated polyclonal antiserum targets ARG1 (Arginase 1), a cytoplasmic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. Antibodies.com supplies it as a 100 µl vial of rabbit polyclonal reagent, unconjugated and validated for Western blot and immunohistochemistry on human, mouse, and rat samples.

ARG1 plays a central role in the hepatic urea cycle and is widely used as a marker of M2-polarized macrophages and of hepatocellular differentiation, supporting work in immunology, hepatology, and tumor biology. The triple-species reactivity profile allows comparative studies between rodent disease models and human tissue specimens within the same experimental design. For research use only.

Recommended applications include Western blot detection of the approximately 35 kDa ARG1 band in cell or tissue lysates, and immunohistochemistry on formalin-fixed paraffin-embedded sections to localize expression in liver, tumor microenvironment, or immune-cell populations. As a polyclonal, the reagent offers broader epitope coverage than a monoclonal clone, which is helpful when probing denatured target or when arginine-metabolism studies generate partially processed fragments.