Anti-ARC Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com targets ARC (Activity-Regulated Cytoskeleton-associated protein), an immediate-early gene product that is rapidly transcribed in neurons in response to synaptic activity and trafficked to active dendritic spines, where it drives AMPA receptor endocytosis and structural remodelling. Because ARC sits at the intersection of long-term potentiation, memory consolidation, and experience-dependent plasticity, antibodies against it are routinely used in neuroscience and synaptic biology laboratories investigating learning, addiction, sleep, and neurodegenerative disease models. The reagent is supplied as 100 µl of antiserum, raised in rabbit, and validated for western blot, immunohistochemistry, and immunofluorescence on human samples, giving researchers flexibility across protein, tissue-section, and subcellular-localization workflows. Being unconjugated, it can be paired with a secondary reagent of choice for fluorescence, HRP, or alkaline-phosphatase detection, and the polyclonal format increases the chance of recognizing multiple epitopes on the ARC protein, which is helpful when probing low-abundance targets or partially degraded samples. For handling, refrigerate on arrival, aliquot on first use to limit freeze-thaw cycles, and protect from light if a conjugated secondary is later added. Always validate on your own system and include appropriate positive controls such as activity-stimulated neuronal cultures or ARC-expressing tissue lysates.