Anti-AR Antibody

The Androgen Receptor (AR) is a ligand-activated nuclear transcription factor that mediates cellular responses to dihydrotestosterone and testosterone, and this rabbit polyclonal antibody from Antibodies.com is raised against it. Supplied as 100 µl at 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, the reagent is unconjugated, giving researchers flexibility to pair it with their preferred secondary antibody or label.

AR governs male reproductive tract development, prostate gland biology, skeletal muscle maintenance, and bone mineralization. Dysregulated AR signaling is implicated in prostate cancer progression, castration-resistant disease, androgen insensitivity syndrome, and spinal and bulbar muscular atrophy (Kennedy disease), making the receptor a frequent focus of translational and basic research programs.

Validated uses include Western blot (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), and immunofluorescence (IF). Reactivity has been confirmed against Human, Mouse, and Rat samples, supporting comparative studies in cell culture, xenograft tissue, and rodent disease models. Polyclonal reactivity is particularly useful for detecting a broader range of AR epitopes, including post-translationally modified or alternatively spliced isoforms.

For handling, aliquot the antibody upon receipt and store at -20°C for long-term use; avoid repeated freeze-thaw cycles and protect from light. The 0.05% sodium azide component acts as a microbial preservative, so the reagent is suitable for use in fixed-cell staining workflows where sodium azide compatibility is maintained.