Anti-AR-β2 (R228) Antibody

Generated against a synthetic peptide spanning the R228 residue within the third intracellular loop of the human Beta-2 Adrenergic Receptor (AR-β2), this rabbit polyclonal antibody from Antibodies.com provides a reagent for studying G-protein coupled receptor signaling. The R228 epitope lies in a region critical for Gs protein coupling and downstream cAMP production, making the antibody a useful tool for probing receptor activation, regulation, and downstream signaling cascades.

Supplied unconjugated at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, the antibody is validated for Western blot (WB) and immunohistochemistry (IHC) and cross-reacts with human, mouse, and rat samples. Each vial contains 50 µl, sufficient for multiple experimental runs and dilution optimization in standard immunoassay workflows.

Beta-2 adrenergic receptors are widely expressed in airway smooth muscle, cardiac tissue, and skeletal muscle, supporting their relevance to pulmonary, cardiovascular, and metabolic research. Investigators studying receptor desensitization, beta-agonist pharmacology, or tissue-specific expression patterns can use this reagent to detect endogenous receptor levels across species and to characterize signaling responses in transfected cell lines and primary tissue sections.