Anti-AQP4 Antibody

Aquaporin-4 (AQP4) is a membrane water channel protein concentrated at astrocyte end-feet along the blood-brain barrier, where it governs water homeostasis in the central nervous system and supports ion-water coupling during neural activity. This unconjugated polyclonal reagent from Antibodies.com is raised in rabbit and validated for western blot and immunohistochemistry across human, mouse, and rat specimens, making it useful for cross-species comparative studies. Common laboratory applications include mapping channel distribution in brain and spinal cord sections, characterizing edema and ischemia models, and investigating neuromyelitis optica spectrum disorder (NMOSD) pathology, where patient-derived autoantibodies target the same extracellular loops recognized in research workflows. The antibody is supplied as 100 µL of polyclonal serum fraction in a vial, ready for dilution into standard immunodetection buffers. For handling, refrigerate short term and aliquot the stock to limit freeze-thaw exposure, preserving binding activity across repeated experiments.