Anti-APPL1 Antibody

This polyclonal reagent from Antibodies.com targets APPL1 (Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1), an endosomal adaptor that links membrane trafficking to Akt and PI3K signaling in mammalian cells. Raised in rabbit and supplied as 100 µl of unconjugated antiserum, the antibody is validated for western blot and immunohistochemistry on human-derived samples, supporting studies of insulin and adiponectin receptor signaling, endocytic trafficking through the Rab5-positive early endosome, and APPL1-dependent regulation of cell survival and proliferation in metabolic disease and oncology research. The polyclonal format broadens epitope coverage across APPL1 isoforms, which is useful when probing endogenous expression that varies between tissue types and experimental conditions. Because the antibody is unconjugated, it can be paired with secondary reporters of the researcher's choice for fluorescence, chemiluminescence, or chromogenic detection, and it is suitable for both lysate-based western blot workflows and fixed-section immunohistochemistry protocols.