Anti-APP (phospho T668) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes the Amyloid Precursor Protein (APP) when phosphorylated at threonine 668 (T668), a regulatory site implicated in APP processing, neuronal differentiation, and Alzheimer's disease pathophysiology. Phosphorylation at T668, which is targeted by kinases such as CDK5 and JNK, modulates APP subcellular trafficking and amyloidogenic cleavage, making site-specific detection valuable in neurodegeneration research.

The antibody is raised in rabbit and is supplied in unconjugated IgG format at a volume of 50 µl. It is validated for Western Blot applications and has been confirmed to react with Human and Mouse samples, supporting its use across cell line and primary tissue models of neuronal function.

As a primary antibody targeting a post-translational modification rather than total APP, it is particularly useful for studies tracking signaling-dependent changes in APP phosphorylation state in response to altered kinase activity, oxidative stress, or disease-associated mutations. The unconjugated format allows flexibility in choosing secondary reagents and detection chemistries tailored to specific Western Blot protocols.