Anti-APP-C31 Antibody

This polyclonal reagent from Antibodies.com specifically recognizes the C-terminal 31-residue fragment of human amyloid precursor protein (APP-C31) generated by caspase cleavage at Asp720. The antibody is validated for western blot, immunocytochemistry, and ELISA workflows, and cross-reacts with mouse and rat samples. Supplied as a liquid in 100 µl aliquots, the IgG preparation is unconjugated for flexible secondary antibody pairing. APP-C31 is a neurotoxic fragment implicated in apoptotic signaling and Alzheimer's disease pathogenesis, and this reagent is used to monitor caspase-dependent APP processing in neuronal cell models and brain tissue lysates. For best results, store aliquots frozen at -20 °C in single-use portions and avoid repeated freeze-thaw cycles to preserve binding activity.