Anti-APP Antibody

This rabbit polyclonal antibody targets the Amyloid Precursor Protein (APP), a type I transmembrane glycoprotein central to neurodegeneration research. APP undergoes sequential proteolytic processing by β- and γ-secretases to generate amyloid-β (Aβ) peptides, whose aggregation into extracellular plaques is a defining pathological hallmark of Alzheimer's disease. Mutations in the APP gene are among the best-characterized causes of familial early-onset Alzheimer's, making APP a focus for studies of disease mechanism, biomarker development, and therapeutic screening.

Supplied as 100 µl of unconjugated rabbit antisera, this reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows using human, mouse, and rat samples. Investigators commonly apply it to detect full-length APP in cell lysates, brain tissue sections, and primary neuronal cultures. Distributed by Antibodies.com, the polyclonal format provides flexibility in secondary antibody and detection chemistry selection, supporting chromogenic, fluorescent, and amplified readouts as required by the experimental system.