Anti-APP Antibody

The amyloid precursor protein (APP) is a single-pass transmembrane glycoprotein encoded on chromosome 21 and best known as the source of amyloid beta peptides that accumulate in the plaques of Alzheimer's disease. This rabbit polyclonal Anti-APP Antibody from Antibodies.com recognizes the endogenous precursor and its proteolytic fragments in human and mouse samples, supporting neuroscience and neurodegeneration research.

Supplied as an unconjugated IgG in a 50 µL vial, the reagent is validated for western blot detection of full-length APP and its C-terminal fragments generated by α-, β-, and γ-secretase cleavage. The polyclonal format allows recognition of multiple epitopes across the extracellular and intracellular regions, supporting studies of processing, trafficking, and post-translational modification. Researchers should aliquot the antibody upon arrival to limit freeze-thaw cycles and preserve reagent activity.

Investigators studying familial Alzheimer's mutations, Down syndrome models in which trisomy of chromosome 21 elevates APP gene dosage, or amyloid biomarker discovery use this reagent to probe APP expression in cell lysates, brain tissue homogenates, and transgenic mouse systems. The unconjugated preparation also permits flexible pairing with custom-labeled secondary antibodies or direct fluorophore conjugation for immunofluorescence workflows.