Anti-APP Antibody

Targeting the Amyloid Precursor Protein (APP), this rabbit polyclonal IgG reagent from Antibodies.com supports investigations into Alzheimer's disease pathogenesis and amyloid-beta biogenesis. The unconjugated antibody is validated for Western blot and immunohistochemistry workflows on human samples, where it enables visualization of full-length APP and its proteolytic fragments in brain tissue and cell lysates. Supplied as 200 µL of polyclonal antiserum, the reagent binds native and denatured APP epitopes, making it a practical choice for studies of secretase-mediated cleavage, neuronal signaling, and neurotoxic plaque formation. Researchers use it to track APP processing in neuronal cell lines, characterize differential expression across brain regions, and probe the molecular mechanisms underlying neurodegeneration.