Anti-APP Antibody

This polyclonal reagent from Antibodies.com targets the amyloid precursor protein, a type I transmembrane glycoprotein implicated in Alzheimer disease pathogenesis and synaptic biology. Raised in rabbit, the unconjugated IgG preparation is supplied as 100 µl of liquid and is validated for Western blot and immunohistochemistry on human samples. The antibody recognizes endogenous APP expressed in brain tissue and in cell lines derived from the nervous system, and is commonly applied to investigate amyloidogenic processing, secretase activity, and plaque-associated pathology. Researchers use this reagent to probe full-length APP and its proteolytic fragments, including soluble APP and the Aβ peptide generated by amyloidogenic cleavage. Suitable for immunoblotting of cell lysates and immunohistochemical staining of brain sections, the antibody offers a flexible tool for studies of neurodegeneration and neural development.