Anti-APP/β-Amyloid (phospho-T668) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically targets amyloid precursor protein phosphorylated at threonine 668, a modification linked to altered amyloid-beta generation and neuronal signaling in Alzheimer's disease models. Supplied as 100 µl of unconjugated reagent at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2, the antibody is validated for western blot and immunohistochemistry on human, mouse, and rat tissue samples. The reagent recognizes the phospho-Thr668 epitope across multiple APP isoforms, supporting studies of kinase-dependent APP processing, neurite outgrowth, and synaptic dysfunction. Researchers probing CK2-, GSK3β-, or JNK-mediated phosphorylation pathways use this reagent with brain tissue and cultured neuron preparations to track disease-relevant signaling events.