Anti-APP/β-Amyloid Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com binds the amyloid precursor protein (APP) and the amyloid-β (Aβ) peptide fragments generated from its proteolytic processing, the principal protein constituents of senile plaques studied in Alzheimer's disease research. The antibody is supplied as 100 µl of stock at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, formatted as a Primary Antibodies reagent for Western blot, immunohistochemistry, and immunofluorescence detection.

Cross-reactivity with human, mouse, and rat APP supports comparative studies in rodent models of neurodegeneration alongside postmortem human tissue analysis. The polyclonal response recognizes multiple epitopes across the APP/Aβ region, enabling simultaneous visualization of full-length APP, its α-, β-, and γ-secretase cleavage products, and the released Aβ peptides of varying aggregation state. Store the glycerol-containing vial at -20°C and aliquot upon first use to limit repeated freeze-thaw cycles of the working stock.