Anti-APOL2 Antibody

APOL2 (Apolipoprotein L2) is a member of the apolipoprotein L family of proteins encoded within a gene cluster on human chromosome 22q12. This rabbit polyclonal reagent from Antibodies.com is raised against recombinant or native human APOL2 and is supplied as an unconjugated preparation in a 100 µl volume. The antibody has been validated for western blot, immunohistochemistry, and immunofluorescence workflows, enabling detection of endogenous APOL2 protein in fixed tissue sections, cultured cells, and standard cell lysates.

APOL2 has been characterized as a lipid-binding protein that participates in cellular lipid transport and has been reported to influence autophagic flux and innate immune signaling in mammalian cells, making the target relevant to research programs in lipid metabolism, host defense, and cancer cell biology. The polyclonal format provides recognition of multiple epitopes across the APOL2 sequence, which can be useful when probing for protein isoforms or when working with samples where post-translational modification may otherwise mask a single linear epitope.

Reactivity is reported for human samples; investigators working with rodent, non-human primate, or other mammalian orthologs should perform their own validation on a representative panel. The product is shipped frozen on dry ice and should be stored at low temperature to preserve reagent activity across multiple freeze-thaw cycles, with small working aliquots recommended for routine bench use. Suggested starting dilutions will vary by application, but typical laboratory ranges for comparable polyclonal reagents are 1:500 to 1:2000 for western blot and 1:50 to 1:200 for immunostaining, and should be optimized empirically by the end user against an appropriate positive control lysate or tissue section.