Anti-ApoE Antibody

Apolipoprotein E (ApoE) is a 299-amino-acid glycoprotein that serves as a ligand for lipoprotein receptors and governs lipid transport and cholesterol homeostasis across peripheral and central nervous system tissues. This unconjugated rabbit polyclonal antibody from Antibodies.com recognizes endogenous ApoE in human, mouse, and rat samples, supporting translational investigation of lipid biology, atherogenesis, and neurodegenerative disease mechanisms.

Raised in rabbit and supplied as a 100 µl liquid aliquot, the reagent is validated for western blot detection of ApoE isoforms, immunohistochemistry localization in tissue sections, and ELISA-based quantification. Researchers working on Alzheimer's disease genetics, where the ε4 allele confers elevated risk, as well as those exploring hepatic lipoprotein assembly or macrophage cholesterol efflux, will find utility across their experimental workflows.

The polyclonal format yields recognition of multiple epitopes, an advantage when probing post-translationally modified or isoform-distinct ApoE species. Combined with reactivity to three mammalian model organisms, the antibody enables comparative studies of lipid handling between human patient samples and rodent disease models without switching primary reagents.