Anti-ApoE Antibody

ApoE (Apolipoprotein E) is a 299-amino-acid secreted glycoprotein that mediates cholesterol transport and lipid homeostasis through binding to LDL receptor family members. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in phosphate buffered saline (pH ~7.2) with 0.05% sodium azide as preservative, validated for Western blot detection of ApoE in human, mouse, and rat samples.

ApoE is most abundant in liver and brain tissue, where it supports triglyceride-rich lipoprotein clearance, neuronal repair, and amyloid-β processing. The E4 isoform in particular is a well-characterized genetic risk factor for late-onset Alzheimer's disease, making this antibody relevant to neurodegeneration, cardiovascular disease, dyslipidemia, and CNS injury research.

The polyclonal format allows recognition of multiple epitopes across the ~34 kDa apolipoprotein, which can improve tolerance to minor sequence variation across the three reactive species and accommodate post-translational modification differences. Each 100 µl vial provides enough material for multiple gel and blot experiments; aliquot upon arrival to limit freeze-thaw cycles, refrigerate, and protect from light.