Anti-APLP2 Antibody

APLP2 (Amyloid Precursor-Like Protein 2) is a widely expressed type I transmembrane glycoprotein belonging to the amyloid precursor protein family, sharing substantial structural homology with APP but lacking the Aβ domain associated with amyloid plaque formation. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against APLP2 and recognizes an epitope conserved across human, mouse, and rat orthologs, enabling comparative studies in both neural and peripheral tissues. The unconjugated format offers flexibility for downstream labeling workflows, and the reagent is validated for Western blot detection of full-length and proteolytically processed APLP2 fragments, immunohistochemistry for tissue localization studies, and immunofluorescence imaging of subcellular distribution in fixed cells. Investigators working on synaptic vesicle cycling, neurite outgrowth, glucose homeostasis, and APP-family proteolytic processing commonly use this reagent to track APLP2 expression and trafficking. Supplied as a 100 µL vial, the polyclonal antibody binds multiple epitopes on the target, which can enhance signal strength in detection assays. Applications include Alzheimer's disease modeling, neuronal development research, and metabolic signaling studies where this APP-family member has been implicated through genetic and biochemical analyses.