Anti-APE1 Antibody

Targeting the human APE1 protein (apurinic/apyrimidinic endodeoxyribonuclease 1), this unconjugated rabbit polyclonal reagent from Antibodies.com supports Western blot and immunofluorescence workflows on cultured cells and tissue sections. Supplied at 100 µl, the antibody recognizes APE1, also called APEX1 or REF-1, the approximately 35 kDa nuclear enzyme central to base excision repair of oxidative and alkylation DNA damage, and to the redox regulation of transcription factors such as NF-κB, HIF-1α, and AP-1. Researchers investigating oxidative stress response, tumor progression, and chemoresistance mechanisms use this antibody to profile APE1 expression and subcellular localization in human-derived samples. The polyclonal format enables recognition of multiple epitopes on the target, providing robust signal in Western blot detection and clear immunofluorescence staining of fixed specimens.