Anti-APC Antibody

This rabbit polyclonal antibody from Antibodies.com targets the Adenomatous Polyposis Coli (APC) tumor suppressor protein, a large multifunctional regulator best known for its role as a scaffold in the Wnt/β-catenin signaling pathway. Raised in rabbit and supplied as an unconjugated reagent in a 100 µl vial, the antibody is validated for Western blot, immunohistochemistry, immunofluorescence, and ELISA workflows across human, mouse, and rat samples, supporting studies in colorectal cancer biology, stem cell research, and developmental signaling.

APC acts as a critical negative regulator of β-catenin by promoting its phosphorylation and ubiquitin-mediated degradation, and loss-of-function mutations in the APC gene drive the majority of sporadic colorectal cancers as well as familial adenomatous polyposis. The polyclonal format recognizes multiple epitopes along the protein, which is helpful when working with truncated variants common in tumor samples. Researchers use this reagent to assess APC expression in intestinal epithelium, to map Wnt pathway activity in mouse models, and to investigate cell adhesion and cytoskeletal roles of APC at the leading edge of migrating cells.