Anti-APBB1 Antibody

Raised in rabbit and unconjugated, this polyclonal reagent from Antibodies.com recognizes APBB1, the amyloid beta precursor protein-binding family B member 1 also called FE65. The antibody is supplied at 100 µl and is validated for western blot, immunohistochemistry, and immunofluorescence workflows.

APBB1 functions as a cytoplasmic adapter that links the amyloid beta precursor protein to cytoskeletal and transcriptional regulatory networks, with documented roles in the DNA damage response, chromatin remodeling, and apoptosis regulation. Researchers investigating Alzheimer's disease models, neuronal signaling pathways, and stress-induced gene expression commonly use antibodies raised against this target.

The reagent shows reactivity against human, mouse, and rat samples, enabling cross-species comparative studies in tissue lysates and fixed sections. With rabbit as the host species and polyclonal clonality, the unconjugated format allows straightforward integration into standard HRP- or fluorophore-based detection chemistries without a conjugated reporter.