Anti-AP2A2 Antibody

The AP-2 adaptor complex subunit alpha 2 (AP2A2) is a component of the heterotetrameric clathrin adaptor that drives receptor-mediated endocytosis at the plasma membrane. This rabbit polyclonal antibody from Antibodies.com was raised against AP2A2 and is supplied as an unconjugated 100 µL liquid aliquot. It has been validated for Western blot and immunohistochemistry, detecting the endogenous protein in human, mouse, and rat samples. AP2A2 partners with the paralog AP2A1 to assemble the adaptor complex that recognizes tyrosine-based YXXΦ and dileucine [DE]XXXL[LI] sorting motifs on transmembrane cargo, recruiting clathrin and supporting coated-vesicle formation during clathrin-mediated endocytosis.