Anti-AP1S2 Antibody

The AP1S2 gene encodes the sigma-2 subunit of the heterotetrameric adaptor protein complex-1 (AP-1), which mediates clathrin-dependent sorting of cargo between the trans-Golgi network and endosomes. Antibodies.com offers this rabbit polyclonal reagent as an unconjugated antiserum raised against the human AP1S2 target, validated for Western blot (WB) and immunofluorescence (IF) applications on human samples. Each vial contains 100 µl of antibody, an amount that supports multiple immunoblotting and imaging experiments when titrated appropriately for membrane-based or fixed-cell workflows. The polyclonal nature of the reagent, raised in a rabbit host, allows researchers to pair the antibody with multiple anti-rabbit secondary reagents for chemiluminescent or fluorescence readouts. Because loss-of-function variants in AP1S2 are causative for Fried syndrome (X-linked intellectual disability) and are implicated in non-syndromic cognitive disorders, the antibody is relevant for studies of neuronal protein trafficking, Golgi-endosomal sorting dynamics, and rare-disease model validation. Storing aliquots refrigerated and avoiding repeated freeze-thaw cycles preserves activity across long-running studies in vesicular transport and neurodevelopmental research.