Anti-Annexin VI Antibody

Annexin VI (also called Annexin A6) is a calcium-dependent phospholipid-binding protein of the annexin family, widely studied for its roles in membrane organization, vesicle trafficking, and as a scaffolding platform at membrane microdomains. This polyclonal reagent from Antibodies.com is raised in rabbit against the human Annexin VI target and is validated for Western blotting, immunohistochemistry, immunofluorescence, and ELISA workflows. Provided unconjugated as 100 µl of antiserum, it offers flexibility for both chromogenic and fluorescence detection schemes in fixed or lysed specimens.

Annexin VI participates in endocytic and exocytic pathways, regulates cholesterol homeostasis, and modulates ion channel behavior, which has made it a marker of interest in studies of cardiac myocyte physiology, hepatocellular carcinoma progression, and lipid-storage disorders. Because polyclonal antibodies engage multiple epitopes on the target, the reagent is well suited to applications where robust signal from low-abundance samples is required and where isoform-level detection across Annexin VI variants is desirable.

Storage at -20 °C in working aliquots helps preserve antibody activity and limit freeze-thaw damage, and the unconjugated format allows researchers to couple the antibody to HRP, biotin, or fluorophores of their choice depending on the secondary detection strategy.

The reagent is commonly paired with antibodies against Annexin II, Annexin V, or caveolin family members when investigating membrane-domain biology, and it has been used alongside markers such as CD63 and LAMP1 in studies of exosome release and lysosomal trafficking.