Anti-Annexin A6 Antibody

This rabbit polyclonal reagent from Antibodies.com targets Annexin A6, a 68 kDa calcium-dependent phospholipid-binding protein implicated in membrane-cytoskeleton dynamics, endosomal sorting, and cholesterol homeostasis. The unconjugated antibody is supplied as 100 µl of polyclonal antiserum raised in rabbit and is reactive with human samples, with validated application in Western Blot (WB), Immunohistochemistry (IHC), and Immunofluorescence (IF) workflows.

Annexin A6 associates with lipid rafts and the plasma membrane to coordinate vesicle trafficking and has been investigated as a regulator of receptor signaling in hepatocytes, cardiomyocytes, and several cancer cell models, where altered expression has been linked to proliferation, migration, and chemoresistance. Researchers use anti-Annexin A6 antibodies to map subcellular distribution, study annexin-mediated membrane repair, and probe interactions with partners such as EGFR signaling and Ras-family GTPases in cell biology research.

For sample preparation, the antibody is applied to fixed cells or tissue sections in IHC and IF, and to lysates for WB detection, with appropriate secondary antibodies selected for the chosen detection method. Store refrigerated and protect from light, and aliquot upon first use to limit freeze-thaw cycles when working with the 100 µl vial format.