Anti-Annexin A1 Antibody

This unconjugated rabbit polyclonal antibody targets Annexin A1, a 37 kDa calcium-dependent phospholipid-binding protein belonging to the annexin superfamily. Annexin A1, also known as lipocortin-1, mediates many of the anti-inflammatory effects of glucocorticoids by engaging formyl peptide receptors on leukocytes, where it modulates cell migration, phagocytic clearance, and downstream cytokine release. Antibodies.com supplies this reagent for studies that map endogenous ANXA1 expression across human tissues and cell lines.

Validated applications include Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF), so the antibody can be used to detect ANXA1 in whole-cell lysates, formalin-fixed tissue sections, or cultured cells. It is supplied as a 100 µl vial of polyclonal antiserum raised in rabbit and is unconjugated, which lets each laboratory pair it with the fluorophore- or enzyme-labeled secondary reagent that best fits its detection platform.

Reactivity has been confirmed against human Annexin A1, supporting work in immunology, inflammation biology, and oncology research where altered ANXA1 expression has been linked to neutrophil dysfunction, tumor progression, and dysregulated glucocorticoid signaling.