Anti-Angptl1 Antibody

Rabbit polyclonal antibody raised against angiopoietin-like protein 1 (Angptl1), supplied by Antibodies.com as a 100 µl aliquot at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2. This unconjugated primary reagent is validated for Western blot (WB) and immunohistochemistry (IHC) workflows and cross-reacts with human, mouse, and rat samples, supporting comparative studies across species. Brief handling guidance: keep refrigerated; aliquot upon first use to limit freeze-thaw cycles of the stock.

Angptl1 is a secreted glycoprotein of the angiopoietin-like family, implicated in lipid and glucose metabolism, vascular remodeling, and inflammatory signaling. Published studies have used anti-Angptl1 reagents to probe expression in liver, adipose, and tumor tissue, including its reported tumor-suppressor function in hepatocellular carcinoma models and contributions to angiogenesis. The polyclonal format provides broad epitope recognition, useful when endogenous Angptl1 levels are low or when working with denatured lysates in Western blot applications.

For immunohistochemistry, the antibody is compatible with standard formalin-fixed paraffin-embedded (FFPE) sections when paired with appropriate antigen retrieval. Conjugation-free format gives researchers freedom to pair it with HRP, fluorophore, or biotin secondary reagents depending on the detection chemistry. For research use only.