Anti-Amyloid Precursor Protein Antibody

This Antibodies.com rabbit polyclonal reagent targets the endogenous Amyloid Precursor Protein (APP), a type I transmembrane glycoprotein expressed in neuronal and non-neuronal tissues. Validated for Western blot and immunocytochemistry (ICC) workflows, the antibody recognizes human, mouse, and rat APP, supporting comparative studies across model systems. APP undergoes sequential cleavage by β- and γ-secretases to liberate amyloid-β (Aβ) peptides, and detection of full-length APP and its C-terminal fragments is widely used to investigate Alzheimer's disease pathology, synaptic biology, and neuronal differentiation. The reagent is supplied as a 100 µl liquid aliquot in an unconjugated IgG format, allowing flexible labeling with secondary reagents of the user's choice. For short-term use, store at 4 °C; for longer storage, aliquot and freeze at -20 °C to limit freeze-thaw cycles and preserve binding activity. For research use only.