Anti-Amyloid Precursor Protein Antibody

This rabbit polyclonal antibody from Antibodies.com specifically recognizes Amyloid Precursor Protein (APP), a type I transmembrane glycoprotein widely expressed in neuronal tissue. APP undergoes sequential proteolytic cleavage by β- and γ-secretases to release amyloid-β (Aβ) peptides, whose extracellular aggregation forms the characteristic amyloid plaques of Alzheimer's disease brain. The unconjugated IgG reagent is supplied as 100 µl of liquid and is validated for western blot (WB), immunocytochemistry (ICC), and immunohistochemistry (IHC) on human, mouse, and rat samples, supporting research into APP processing, Aβ generation, and neurodegeneration. For long-term use, store aliquots frozen at -20 °C and avoid repeated freeze-thaw cycles to preserve antibody titer.