Anti-Amyloid beta Peptide 42 Antibody [NT 6C8]

A mouse monoclonal primary antibody specific for the 42-amino-acid amyloid-beta isoform (Aβ42) that constitutes the core of senile plaques in Alzheimer's disease, this Antibodies.com reagent (clone NT 6C8) recognises an N-terminal epitope on Aβ42 and is widely used to distinguish Aβ42 from the more abundant Aβ40 species in neuroscience research.

Supplied as 100 µg of lyophilised powder in a single vial, the antibody is unconjugated and of the IgG1 isotype, leaving the choice of secondary reporter or custom conjugation chemistry open to the user. Host species is mouse, with reactivity confirmed against human Aβ42. The reagent is validated for immunohistochemistry on human brain tissue, including formalin-fixed paraffin-embedded sections for plaque visualisation, and for ELISA-based quantification of Aβ42 in research samples.

Lyophilised format provides extended shelf stability during shipping; once reconstituted, the antibody is best divided into single-use frozen aliquots to limit freeze-thaw cycles and preserve binding activity across repeated experiments. Researchers studying amyloid plaque burden, amyloid precursor protein processing, and the relative ratios of Aβ42 to Aβ40 in disease versus control tissue rely on isoform-selective antibodies such as clone NT 6C8 to generate reproducible quantitative read-outs in both tissue imaging and plate-based assays.