Anti-Amyloid beta Peptide 42 Antibody [NT 1H3]

Targeting the 42-residue amyloidogenic isoform central to Alzheimer's disease plaque pathology, this unconjugated mouse monoclonal reagent from Antibodies.com is raised against an N-terminal epitope of Aβ42 and supplied as 100 µg of lyophilised powder. Clone NT 1H3 binds the N-terminus of the peptide rather than its C-terminus or central hydrophobic region, supporting selective detection of full-length Aβ42 species in human brain tissue and translational disease models.

Host is Mouse with isotype IgG1, and the unconjugated format gives researchers flexibility to pair it with secondary detection reagents of their choice for immunohistochemistry on formalin-fixed paraffin-embedded sections. Validated applications include IHC for amyloid plaque localization in cortical and hippocampal regions. Reconstitution yields a working stock suitable for short-term refrigerated storage, and the lyophilised format protects activity during shipment; aliquots are recommended to limit freeze-thaw cycling. Reactivity is reported for human samples, making this primary antibody a focused tool for Alzheimer's biomarker studies, plaque-burden quantification, and therapeutic screening workflows.