Anti-Alpha-Synuclein Antibody [4C1]

Primary Antibodies from Antibodies.com include this monoclonal reagent raised against Alpha-Synuclein, a 140-residue presynaptic protein whose aggregation into Lewy bodies is the pathological hallmark of Parkinson's disease and related synucleinopathies such as Dementia with Lewy Bodies and Multiple System Atrophy. The clone 4C1 is produced in mouse and is of the IgG2a isotype; the antibody is supplied unconjugated, in lyophilised form at 100 µg per vial, which keeps it stable during shipping without cold-chain logistics and allows reconstitution in the laboratory buffer of choice.

Researchers use it in ELISA and Western blot workflows to detect total Alpha-Synuclein in human samples, supporting studies of oligomerisation, phosphorylation at Ser129, and the differentiation of physiological monomers from pathological fibrillar aggregates. Its reactivity is restricted to human Alpha-Synuclein, making it a useful tool for disease-model validation, biomarker assay development, and confirmation of findings in patient-derived biospecimens by immunoblot or immunohistochemistry. The unconjugated presentation allows end users to couple it to their preferred reporter, bead, or secondary-detection system, and the lyophilised format reconstitutes readily for downstream use in vitro and in research use only applications.