Anti-Alpha-Synuclein Antibody [4B4]

Alpha-synuclein is a 140-amino-acid presynaptic protein encoded by the SNCA gene and a defining component of Lewy bodies, the intraneuronal inclusions characteristic of Parkinson's disease pathology. The Antibodies.com Anti-Alpha-Synuclein Antibody [4B4] is a mouse monoclonal IgG2a reagent raised against this target, validated for ELISA and Western blot workflows on human samples. Supplied as 100 µg of lyophilised product in an unconjugated format, the antibody supports studies of alpha-synuclein expression, aggregation, and post-translational modification in both cell and tissue lysates. The 4B4 clone has been referenced in research examining soluble monomers and higher-order oligomeric species, making it a practical tool for synucleinopathy and neurodegeneration investigations. Following standard reconstitution of the lyophilised pellet, the reagent is ready for immunoblotting at expected band sizes near the 14 kDa monomer or in aggregated assemblies. Researchers developing biomarkers, characterizing SNCA mutations, or profiling Lewy body pathology can rely on this reagent for reproducible detection.