Anti-Alpha-1A adrenergic receptor Antibody

This rabbit polyclonal antibody targets the Alpha-1A adrenergic receptor (ADRA1A), a G protein-coupled receptor encoded by the ADRA1A gene that mediates vasoconstriction and smooth muscle contraction through Gq signaling and downstream phospholipase C activation. Raised in rabbit and supplied as an unconjugated reagent at 100 µl, the antibody is validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) applications on human samples.

ADRA1A is expressed in tissues including vascular smooth muscle, the prostate, bladder neck, heart, and central nervous system, where it contributes to sympathetic regulation of vascular tone and lower urinary tract function. Researchers studying cardiovascular pharmacology, benign prostatic hyperplasia, or GPCR signaling pathways commonly use this reagent to localize receptor expression in tissue sections and to confirm protein levels in cell lysates.

The polyclonal format provides multi-epitope recognition of the receptor, useful when a single monoclonal clone fails to detect the target across varied sample preparations. Store refrigerated in the original vial and avoid repeated freeze-thaw cycles to preserve activity across blotting and staining workflows. Provided by Antibodies.com as a research-use-only reagent.