Anti-alpha 1 Antichymotrypsin Antibody [B7H2]

Mouse IgG1 monoclonal antibodies targeting alpha 1 antichymotrypsin (SERPINA3) support research into acute-phase inflammation and amyloid pathology, and the B7H2 clone from Antibodies.com is supplied as a lyophilised 100 µg vial validated for western blot detection of the human protein.

Alpha 1 antichymotrypsin modulates extracellular proteolysis by neutralizing chymotrypsin-like enzymes released from activated neutrophils, and altered expression is documented in hepatocellular carcinoma, lung adenocarcinoma, and glioblastoma contexts. Investigators use anti-SERPINA3 reagents to monitor hepatic stress, characterize tumor-associated proteostasis, and probe glial responses in neurodegeneration models. The lyophilised presentation extends shelf stability under refrigerated storage; reconstitution in sterile buffer should be performed shortly before use, and aliquoting helps limit freeze-thaw cycles once the antibody is in solution.

Working dilutions should be titrated empirically for each membrane system and detection chemistry. The unconjugated format permits flexible downstream labelling with HRP, biotin, or fluorophores, allowing adaptation to chromogenic, chemiluminescent, or fluorescence-based western blot workflows.